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Abstract #0004

Low-Angle Combined-Echo (LACE) Imaging in Highly Inhomogeneous B0 Magnetic Fields

Sebastian Theilenberg1, Chathura Kumaragamage2, Scott McIntyre2, Terry W. Nixon2, Christoph Juchem1,3, and Robin A. de Graaf2
1Biomedical Engineering, Columbia University, New York, NY, United States, 2Department of Radiology and Biomedical Imaging, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, CT, United States, 3Radiology, Columbia University Medical Center, New York, NY, United States

In line with recent developments in scanner design for more cost effective and more accessible scanners, we propose a low-angle combined-echo sequence similar to a conventional spin echo sequence capable of producing high quality images in the presence of strong B0 inhomogeneity. We present simulation results investigating the signal dependence on the sequence’s timings and flip angles as well as image contrast for typical relaxation times of normal brain white and gray matter. The simulations were validated in vivo at 4 T. Lastly, we show the feasibility to utilize multi-coil generated image encoding fields for this sequence.

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