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Abstract #0005

Interleaved MRI and DMI on human brain in vivo

Yanning Liu1, Henk M. De Feyter1, Scott McIntyre1, Terence W. Nixon1, and Robin A. de Graaf1
1MRRC Yale University, New Haven, CT, United States

Deuterium metabolic imaging (DMI) is a powerful method to map metabolism in vivo. To integrate DMI with clinical MRI, we propose and demonstrate an interleaved MRI and DMI routine, including the necessary hardware and sequence modifications. Using interleaved FLAIR MRI+DMI as an example, we demonstrate that MR image quality and DMI sensitivity as well as information content are preserved, both in phantoms and in the human brain in vivo. The interleaved MRI+DMI technology provides full flexibility to extend any MRI protocol with DMI, thereby offering a metabolic component to the range of MR imaging contrasts.

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