Recently, several studies have shown that brain tissue consists of microscopically heterogeneous components that are characterized by different T2 values and diffusivity. The joint relaxation-diffusion MRI technique has been developed to probe the intrinsic tissue microstructure that cannot be probed using standard dMRI. However, a major limitation of the relaxation-diffusion MRI technique is the long scan time for acquiring dMRI with multiple TEs. In order to significantly reduce the scan time, we propose a time-division multiplexing based echo-planar imaging (TDM-EPI) sequence, which can accelerate relaxation-diffusion MRI and standard dMRI by 2 or 3 folds.
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