Abstract #0006

Accelerated diffusion and relaxation-diffusion magnetic resonance imaging using time-division multiplexing echo-planar imaging (TDM-EPI)

Yang Ji^1,2, Borjan Gagoski ^2,3, W. Scott Hoge ^1,2, Yogesh Rathi ^1,2, and Lipeng Ning ^1,2

¹Brigham and Women’s Hospital, Boston, MA, United States, ²Harvard Medical School, Boston, MA, United States, ³Boston Children’s Hospital, Boston, MA, United States

Recently, several studies have shown that brain tissue consists of microscopically heterogeneous components that are characterized by different T2 values and diffusivity. The joint relaxation-diffusion MRI technique has been developed to probe the intrinsic tissue microstructure that cannot be probed using standard dMRI. However, a major limitation of the relaxation-diffusion MRI technique is the long scan time for acquiring dMRI with multiple TEs. In order to significantly reduce the scan time, we propose a time-division multiplexing based echo-planar imaging (TDM-EPI) sequence, which can accelerate relaxation-diffusion MRI and standard dMRI by 2 or 3 folds.

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