Abstract #0037

Simultaneous 18F-FDG-PET and 1H-MRSI in Temporal Lobe Epilepsy Reveals Metabolic Alterations Concordant with SEEG Epileptogenicity

Hui Huang¹, Jia Wang¹, Miao Zhang², Wei Liu³, Lihong Tang¹, Yibo Zhao^4,5, Rong Guo^4,5, Yudu Li^4,5, Zhi-Pei Liang^4,5, Yao Li¹, Biao Li², and Jie Luo¹

¹School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ²Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ³Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁴Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, Urbana, IL, United States, ⁵Beckman Institute for Advanced Sciences and Technology, University of Illinois at Urbana Champaign, Urbana, IL, United States

Both PET and MRSI could provide metabolic information of the epileptogenic zone, which could add value to presurgical planning of epilepsy patients. This study investigated metabolic alternations in patients with temporal lobe epilepsy (TLE) across their brain regions with different epileptogenicity, as defined using stereo-EEG (SEEG). Our experimental results showed FDG hypometabolism and NAA decrease in epileptogenic zone and propagation zone. These findings may lay a foundation for further investigation of tissue damage associated with epileptogenicity using high-resolution metabolic imaging.

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