Abstract #0039

Seizure frequency in relation to effective connectivity of the hippocampal–diencephalic–cingulate in temporal lobe epilepsy

Yao-Chia Shih^1,2,3, Fa-Hsuan Lin^4,5, Aeden Kuek Zi Cheng¹, Horng-Huei Liou^6,7, and Wen-Yih Isaac Tseng^3,7,8,9

¹Department of Diagnostic Radiology, Singapore General Hospital, Singapore, Singapore, ²Duke-NUS Medical School, Singapore, Singapore, ³Institute of Medical Device and Imaging, College of Medicine, National Taiwan University, Taipei, Taiwan, ⁴Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ⁵Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada, ⁶Department of Neurology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan, ⁷Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan, ⁸Department of Medical Imaging, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan, ⁹Molecular Imaging Center, National Taiwan University, Taipei, Taiwan

To seek neural correlates of seizure recurrence, the structural equation modeling (SEM) and resting-state functional MRI were performed to evaluate intrinsic effective connectivity (iEC) within the Papez circuit, hippocampal–diencephalic–cingulate (HDC) model, and simplified HDC model in patients with left and right temporal lobe epilepsy. We verified that the simplified HDC model was the best model to estimate iEC and found associations between seizure frequency and aberrant iEC on the paths connecting to the mammillary body. Our findings could facilitate the discovery of potential epilepsy pathways and the development of novel targeted therapies for unilateral temporal lobe epilepsy.

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