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Abstract #0040

Mild Traumatic Brain Injury Predisposes to Thalamic Reticular Nucleus Impairment and Thalamocortical Dysrhythmia

Yi-Tien Li1,2, Duen-Pang Kuo2,3, Yun-Ting Lee2, Yung-Chieh Chen2,3, Hsiao-Wen Chung4, and Cheng-Yu Chen2,3,5,6
1Neuroscience Research Center, Taipei Medical University, Taipei, Taiwan, 2Translational Imaging Research Center, Taipei Medical University Hospital, Taipei, Taiwan, 3Department of Medical Imaging, Taipei Medical University Hospital, Taipei, Taiwan, 4Graduate Institute of Biomedical Electrics and Bioinformatics, Taipei, Taiwan, 5Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, 6Research Center for Artificial Intelligence in Medicine, Taipei Medical University, Taipei, Taiwan

This study is the first to provide strong evidence that thalamocortical dysrhythmia (TCD) is involved in mild traumatic brain injury (mTBI) and plays a crucial role in protracted symptoms. The impaired cortical–thalamic tracts and thalamic reticular nuclei are recognized as two pathomechanisms of TCD in mTBI. TCD-induced thalamocortical disinhibition, such as within-thalamus hyperconnectivity, widespread low-frequency thalamocortical coherence, and thalamo-default-mode network disinhibition, are associated with patients’ prolonged symptoms, which were consistently presented at 1- and 2-year follow-ups. Our systematic analysis strengthens understanding of TCD involvement in mTBI and provides future directions for diagnosis, prognosis, and treatment of long-lasting symptoms in mTBI.

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