Abstract #0040

Mild Traumatic Brain Injury Predisposes to Thalamic Reticular Nucleus Impairment and Thalamocortical Dysrhythmia

Yi-Tien Li^1,2, Duen-Pang Kuo^2,3, Yun-Ting Lee², Yung-Chieh Chen^2,3, Hsiao-Wen Chung⁴, and Cheng-Yu Chen^2,3,5,6

¹Neuroscience Research Center, Taipei Medical University, Taipei, Taiwan, ²Translational Imaging Research Center, Taipei Medical University Hospital, Taipei, Taiwan, ³Department of Medical Imaging, Taipei Medical University Hospital, Taipei, Taiwan, ⁴Graduate Institute of Biomedical Electrics and Bioinformatics, Taipei, Taiwan, ⁵Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ⁶Research Center for Artificial Intelligence in Medicine, Taipei Medical University, Taipei, Taiwan

This study is the first to provide strong evidence that thalamocortical dysrhythmia (TCD) is involved in mild traumatic brain injury (mTBI) and plays a crucial role in protracted symptoms. The impaired cortical–thalamic tracts and thalamic reticular nuclei are recognized as two pathomechanisms of TCD in mTBI. TCD-induced thalamocortical disinhibition, such as within-thalamus hyperconnectivity, widespread low-frequency thalamocortical coherence, and thalamo-default-mode network disinhibition, are associated with patients’ prolonged symptoms, which were consistently presented at 1- and 2-year follow-ups. Our systematic analysis strengthens understanding of TCD involvement in mTBI and provides future directions for diagnosis, prognosis, and treatment of long-lasting symptoms in mTBI.

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