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Abstract #0041

Improvements in neuropsychological functioning and recoveries in brain structures and functions in inactive professional fighters

Xiaowei Zhuang1,2, Lauren Bennett3, Virendra Mishra1, Zhengshi Yang1,2, Karthik Sreenivasan1,2, Aaron Ritter1, Charles Bernick1,4, and Dietmar Cordes1,2,5
1Lou Ruvo Center For Brain Health, Cleveland Clinic, Las Vegas, NV, United States, 2University of Nevada, Las Vegas, Las Vegas, NV, United States, 3Hoag Memorial Hospital Presbyterian, Newport Beach, CA, United States, 4UW Medicine, Seattle, WA, United States, 5University of Colorado Boulder, Boulder, CO, United States

Longitudinal changes in fighters’ cognitive performance and brain structural (cortical thickness) and functional (seeded functional connectivity) measures following their transitions to inactive fighting status were investigated and compared with fighters who remain active. A linear mixed effect model was applied for each measure. When fighters transitioned to inactive status, improvements in cognitive performances, structural thickness measures and related functional connectivity measures are evident. In contrast, in fighters who continue to compete in professional matches, neuropsychological performances and structural and functional brain measures are observed to remain largely stable or reflect subtle declines across time points.

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