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Abstract #0406

A time-efficient OGSE sequence with spiral readout for an improved depiction of diffusion dispersion

Eric Seth Michael1, Franciszek Hennel1, and Klaas Paul Pruessmann1
1Institute for Biomedical Engineering, ETH Zurich and University of Zurich, Zurich, Switzerland

Oscillating gradient spin-echo (OGSE) sequences typically suffer low diffusion sensitization and long echo times, thereby compromising the diffusion-to-noise ratio (DNR). To address these issues, recently proposed OGSE shapes providing increased diffusion sensitization were combined with single-shot spiral readout trajectories using a high-performance gradient system. This implementation was used to study the frequency dependence of diffusivity in the in-vivo human brain for OGSE frequencies up to 125 Hz and b-values up to 1000 s/mm2, yielding an improved depiction of diffusion dispersion. The results indicate the significance of higher b-values in characterizing this relationship.

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