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Abstract #0420

Renal perfusion imaging with free-breathing pCASL MRI in persons with salt-sensitive blood pressure

Michael Pridmore1, Maria Garza1, Laura Jones2, Cassandra Reynolds2, Deepak Gupta2, Manus Donahue1, and Rachelle Crescenzi1
1Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 2Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, United States

Salt sensitive blood pressure is a major independent risk factor for cardiovascular disease, with estimated 50% prevalence in adults for which no imaging biomarker exists. We evaluated persons for salt sensitivity and applied a quantitative magnetic resonance imaging strategy in the kidneys for measuring renal blood flow using free-breathing pseudo-continuous arterial spin labeling. Group comparisons showed renal blood flow is reduced in subjects with salt-sensitivity, which may be linked to renal mechanisms of sodium handling. Additionally, image acquisition protocols were compared between 20x and 4x acquisitions, revealing 4x acquisitions were robust to motion and favored a clinically feasible scan time.

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