Salt sensitive blood pressure is a major independent risk factor for cardiovascular disease, with estimated 50% prevalence in adults for which no imaging biomarker exists. We evaluated persons for salt sensitivity and applied a quantitative magnetic resonance imaging strategy in the kidneys for measuring renal blood flow using free-breathing pseudo-continuous arterial spin labeling. Group comparisons showed renal blood flow is reduced in subjects with salt-sensitivity, which may be linked to renal mechanisms of sodium handling. Additionally, image acquisition protocols were compared between 20x and 4x acquisitions, revealing 4x acquisitions were robust to motion and favored a clinically feasible scan time.
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