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Abstract #0428

Grey matter atrophy measured in-vivo with 9.4T MRI in the cuprizone mouse model of demyelination

A. Max Hamilton1,2,3,4, Qandeel Shafqat1,2,3,4, Nils D. Forkert1,2,3, Ying Wu1,2,3,4, and Jeff F. Dunn1,2,3,4
1Department of Radiology, University of Calgary, Calgary, AB, Canada, 2Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, 3Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada, 4Experimental Imaging Center Cumming School of Medicine, University of Calgary, Calgary, AB, Canada

Grey matter atrophy is a marker of progressive disability in multiple sclerosis (MS). To better study atrophy in MS, mouse models that display grey matter loss are needed. A possible candidate is the cuprizone mouse model, which exhibits demyelination, gliosis, and axonal injury. We used high-resolution MRI (37.5x37.5x250μm3) and atlas-based volumetrics to measure volumes of 62 structures in the brains of cuprizone mice following acute (6-weeks) and chronic (12-weeks) demyelination. We found no atrophy associated with acute demyelination but identified atrophy in 7 regions following chronic demyelination including the corpus callosum, internal capsule, striatum, and thalamus.

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