Abstract #0428

Grey matter atrophy measured in-vivo with 9.4T MRI in the cuprizone mouse model of demyelination

A. Max Hamilton^1,2,3,4, Qandeel Shafqat^1,2,3,4, Nils D. Forkert^1,2,3, Ying Wu^1,2,3,4, and Jeff F. Dunn^1,2,3,4

¹Department of Radiology, University of Calgary, Calgary, AB, Canada, ²Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, ³Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada, ⁴Experimental Imaging Center Cumming School of Medicine, University of Calgary, Calgary, AB, Canada

Grey matter atrophy is a marker of progressive disability in multiple sclerosis (MS). To better study atrophy in MS, mouse models that display grey matter loss are needed. A possible candidate is the cuprizone mouse model, which exhibits demyelination, gliosis, and axonal injury. We used high-resolution MRI (37.5x37.5x250μm³) and atlas-based volumetrics to measure volumes of 62 structures in the brains of cuprizone mice following acute (6-weeks) and chronic (12-weeks) demyelination. We found no atrophy associated with acute demyelination but identified atrophy in 7 regions following chronic demyelination including the corpus callosum, internal capsule, striatum, and thalamus.

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