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Abstract #0429

Optogenetic fMRI Reveals Distinct Response Characteristics of Sensory and Limbic Thalamic Spindle-like Activities

Xunda Wang1,2, Alex T. L. Leong1,2, and Ed X. Wu1,2
1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China, 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China

Spindle-like activities constitute one of the most critical brain-wide oscillatory activities for memory consolidation. Spindle-like activities with different temporal characteristics have been associated with heterogeneous distribution patterns. Studies postulated that such heterogeneous distribution and differences in temporal characteristics of spindle-like activities were determined by differences in corresponding spindle-generation thalamo-cortical circuits. However, no direct evidence has been shown. In this study, we demonstrate distinct brain-wide targets but similar temporal-characteristics dependent cross-modal recruitment property of limbic and sensory thalamically-evoked spindle-like activities. Our work provides direct evidence that spindle-like activities initiated from distinct thalamic nuclei can recruit distinct brain-wide targets

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