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Abstract #0430

Polarity of BOLD fMRI as a function of balance between excitation and inhibition

Kostiantyn Cherkas1, G. H. Im1, and S.G. Kim2
1Cener for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS), Suwon 16419, Republic of Korea, Suwon, Korea, Republic of, 2Cener for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS), Suwon 16419, Republic of Korea, Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Suwon, Korea, Republic of

To investigate neural source of positive and negative BOLD signals, we modulated a balance of excitatory and inhibitory activity (EI) within the same somatosensory area to determine whether the polarity of evoked BOLD response is reversed. We measured BOLD fMRI at 15.2T and calcium photometry of ketamine/xylazine-anesthetized mice in response to frequency dependent whisker pad stimulation. At 4 Hz, positive BOLD and increased calcium activity were observed in the barrel cortex, whereas at 20 Hz stimulation, negative BOLD and decreased calcium activity were detected. This indicates that the BOLD polarity closely links to the EI balance.

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