Abstract #0431

Validation of MRI Measurements of Myelination Changes in an Absence Epilepsy Mouse Model

Gustavo Chau Loo Kung¹, Juliet Knowles², Lijun Ni², John Huguenard², Michelle Monje², and Jennifer McNab³

¹Bioengineering Department, Stanford University, Stanford, CA, United States, ²Neurology Department, Stanford University, Stanford, CA, United States, ³Radiology Department, Stanford University, Stanford, CA, United States

Maladaptive myelination may contribute to both the predisposition to seizures and cognitive impairment in diseases such as absence epilepsy. To support this hypothesis, we performed MRI microstructural measurements in ex vivo mouse brains from the Scn8amed+/- model of absence epilepsy and validated them against matching Electron Microscopy (EM) quantifications. Our MRI g-ratio results strongly agree with these measurements and both show a statistically significant decrease in g-ratio of the genu in seizure mice. Future work will look to continue the current analysis in longitudinal studies to probe the previously unknown effects of dynamic myelination on the progression of absence epilepsy.

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