Abstract #0582

Characterization of cross-relaxation in human skeletal muscle using downfield 1H MRS at 7T

Sophia Swago¹, Abigail Cember², Brianna Moon¹, Puneet Bagga³, Neil Wilson⁴, Mark A. Elliott², Hari Hariharan², Ravinder Reddy², and Walter Witschey²

¹Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, ²Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ³St. Jude Children's Research Hospital, Memphis, TN, United States, ⁴Siemens Medical Solutions USA Inc, Malven, PA, United States

Water suppression limits the detection of non-labile proton downfield resonances in 1H magnetic resonance spectroscopy (MRS) due to cross-relaxation with water, and the cross-relaxation properties of these resonances has yet to be quantified in human skeletal muscle. We use spectrally-selective excitation in an inversion recovery experiment to compare the apparent T1 relaxation time of downfield resonances in skeletal muscle under selective and nonselective inversion conditions at 7T. Nonselective inversion significantly prolongs the longitudinal relaxation rate of resonances found 8.0, 8.2, and 8.5 ppm. This change is larger for the resonances at 8.2 and 8.5 ppm, indicating a stronger cross-relaxation effect.

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