Water suppression limits the detection of non-labile proton downfield resonances in 1H magnetic resonance spectroscopy (MRS) due to cross-relaxation with water, and the cross-relaxation properties of these resonances has yet to be quantified in human skeletal muscle. We use spectrally-selective excitation in an inversion recovery experiment to compare the apparent T1 relaxation time of downfield resonances in skeletal muscle under selective and nonselective inversion conditions at 7T. Nonselective inversion significantly prolongs the longitudinal relaxation rate of resonances found 8.0, 8.2, and 8.5 ppm. This change is larger for the resonances at 8.2 and 8.5 ppm, indicating a stronger cross-relaxation effect.
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