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Abstract #0582

Characterization of cross-relaxation in human skeletal muscle using downfield 1H MRS at 7T

Sophia Swago1, Abigail Cember2, Brianna Moon1, Puneet Bagga3, Neil Wilson4, Mark A. Elliott2, Hari Hariharan2, Ravinder Reddy2, and Walter Witschey2
1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 2Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 3St. Jude Children's Research Hospital, Memphis, TN, United States, 4Siemens Medical Solutions USA Inc, Malven, PA, United States

Water suppression limits the detection of non-labile proton downfield resonances in 1H magnetic resonance spectroscopy (MRS) due to cross-relaxation with water, and the cross-relaxation properties of these resonances has yet to be quantified in human skeletal muscle. We use spectrally-selective excitation in an inversion recovery experiment to compare the apparent T1 relaxation time of downfield resonances in skeletal muscle under selective and nonselective inversion conditions at 7T. Nonselective inversion significantly prolongs the longitudinal relaxation rate of resonances found 8.0, 8.2, and 8.5 ppm. This change is larger for the resonances at 8.2 and 8.5 ppm, indicating a stronger cross-relaxation effect.

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