Abstract #0583

Decreased muscular perfusion in dermatomyositis: initial results detected by Inflow-based vascular-space-occupancy MR imaging

Yuankui Wu¹, Xiaomin Liu¹, Jun Hua^2,3, Xiaodan Li¹, Haimei Cao¹, Yingjie Mei⁴, and Yikai Xu¹

¹Department of Medical Imaging, Nanfang Hospital, Southern Medical University, Guangzhou, China, ²Neurosection, Division of MRI Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Philips healthcare, Guangzhou, China

Dermatomyositis (DM) is a chronic autoimmune microangiopathy. Accurate quantification of muscular microcirculation can assist in early diagnosis and improve clinical outcomes. Inflow-based vascular-space-occupancy (iVASO) is a novel perfusion technique without the need for exogenous contrast agents. This study aimed to determine the potential diagnostic value of iVASO-MRI for patients with DM. The results showed decreased arteriolar muscular blood volume (MBVa) in DM patients, which worsens with the progression of disease, and the diminished MBVa in morphologically-normal appearing muscles. This suggests that iVASO-derived MBVa has the potential to be used as a biomarker for early diagnosis of DM.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.