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Abstract #0689

Characterization of Cardiac Amyloidosis using Cardiac Magnetic Resonance Fingerprinting: Preliminary Results

Brendan L Eck1, Nicole Seiberlich2, Scott D Flamm1,3, Jesse I Hamilton2, Mazen Hanna3, Yash Kumar4, Abhilash Suresh3, Angel Lawrence1,3, W. H. Wilson Tang3, and Deborah Kwon3
1Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, 2Radiology, University of Michigan, Ann Arbor, MI, United States, 3Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, United States, 4Case Western Reserve University, Cleveland, OH, United States

Cardiac amyloidosis is an infiltrative cardiomyopathy characterized by the accumulation of misfolded proteins in the myocardium. Elevated myocardial T1 and T2 have been reported as a potential biomarker of disease. Cardiac Magnetic Resonance Fingerprinting (cMRF) has the potential to provide improved tissue characterization for cardiac amyloidosis through simultaneous T1 and T2 mapping. Furthermore, signal evolutions obtained by cMRF may enable improved tissue characterization. In this preliminary study of cardiac amyloidosis patients, relaxometric quantities and signal evolution data are analyzed. Myocardial T1 and T2 were elevated in patients, and linear discriminant analysis of signal evolution data suggests improved discrimination of disease.

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