Abstract #0689

Characterization of Cardiac Amyloidosis using Cardiac Magnetic Resonance Fingerprinting: Preliminary Results

Brendan L Eck¹, Nicole Seiberlich², Scott D Flamm^1,3, Jesse I Hamilton², Mazen Hanna³, Yash Kumar⁴, Abhilash Suresh³, Angel Lawrence^1,3, W. H. Wilson Tang³, and Deborah Kwon³

¹Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, ²Radiology, University of Michigan, Ann Arbor, MI, United States, ³Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, United States, ⁴Case Western Reserve University, Cleveland, OH, United States

Cardiac amyloidosis is an infiltrative cardiomyopathy characterized by the accumulation of misfolded proteins in the myocardium. Elevated myocardial T₁ and T₂ have been reported as a potential biomarker of disease. Cardiac Magnetic Resonance Fingerprinting (cMRF) has the potential to provide improved tissue characterization for cardiac amyloidosis through simultaneous T₁ and T₂ mapping. Furthermore, signal evolutions obtained by cMRF may enable improved tissue characterization. In this preliminary study of cardiac amyloidosis patients, relaxometric quantities and signal evolution data are analyzed. Myocardial T₁ and T₂ were elevated in patients, and linear discriminant analysis of signal evolution data suggests improved discrimination of disease.

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