Abstract #0793

Quantitative susceptibility imaging to stage acute cerebral hemorrhages: A direct comparison of the mcTFI and MEDI methods

Allen A Champagne^1,2, Yan Wen³, Magdy Selim⁴, Aristotelis Filippidis ⁵, Ajith Thomas⁵, Pascal Spincemaille³, Yi Wang³, and Salil Soman ⁶

¹School of Medicine, Queen's University, Kingston, ON, Canada, ²Center for Neuroscience Studies, Queen's University, Kingston, ON, Canada, ³Radiology, Weill Cornell Medicine, New York, NY, United States, ⁴Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, ⁵Neurosurgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, ⁶Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

The perceived acuity (hyperacute, acute, subacute) of intracerebral hemorrhage (ICH) dramatically impacts patient management. While CT and standard MRI are limited for staging ICH, Quantitative Susceptibility Imaging (QSM) has shown promising results for tracking the evolution of ICH, as a substrate for the pathophysiology within bleeds. Here, we compare novel multi-echo complex total field inversion (mcTFI) QSM for staging ICHs, in comparison to conventional Morphology Enabled Dipole Inversion (MEDI). mcTFI better distinguished hyperacute/acute timepoints from subacute ICHs, in comparison to MEDI, likely as a result of the robust inversion computation, inherently reducing susceptibility quantification errors and shadowing artifacts.

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