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Abstract #0794

The Effect of Oblique Image Slices on the Accuracy of Quantitative Susceptibility Mapping and a Robust Tilt Correction Method

Oliver C. Kiersnowski1, Anita Karsa1, John S. Thornton2, and Karin Shmueli1
1Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 2UCL Queens Square Institute of Neurology, London, United Kingdom

Quantitative susceptibility mapping (QSM) using the MRI phase to calculate tissue magnetic susceptibility is finding increasing clinical applications. Oblique image slices are often acquired to facilitate radiological viewing and reduce artifacts. Here, we show that artifacts and errors arise in susceptibility maps if oblique acquisition is not properly taken into account in QSM. We performed a comprehensive analysis of the effects of oblique acquisition on brain susceptibility maps and compared tilt correction schemes for three susceptibility calculation methods, using a numerical phantom and human in-vivo images. We demonstrate a robust tilt correction method for accurate QSM with oblique acquisition.

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