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Abstract #0994

Cardiac 1H MRS detected reduced myocardial triglycerides after Doxorubicin injection: an in vivo animal study

Xiaoying Cai1,2, Selcuk Kucukseymen2, Maria-Alexandra Olaru3, Patrick Pierce2, Beth Goddu2, Jennifer Rodriguez2, and Reza Nezafat2
1Siemens Medical Solutions USA, Inc., Boston, MA, United States, 2Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States, 3Siemens Healthcare Limited GB&I, Frimley, United Kingdom

Cardiotoxicity remains a side effect of chemotherapy agents. Non-invasive imaging including cardiac MR has been applied to assess cardiac injury in patients receiving chemotherapy. Alterations in cardiac energetics have been reported in previous studies but have not been widely investigated in vivo. In this study, single voxel 1H spectroscopy was applied to detect lipid metabolism changes in a large animal model. The results showed reduced myocardial triglycerides content in the doxorubicin-treated group in comparison with the control group.

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