Cardiotoxicity remains a side effect of chemotherapy agents. Non-invasive imaging including cardiac MR has been applied to assess cardiac injury in patients receiving chemotherapy. Alterations in cardiac energetics have been reported in previous studies but have not been widely investigated in vivo. In this study, single voxel 1H spectroscopy was applied to detect lipid metabolism changes in a large animal model. The results showed reduced myocardial triglycerides content in the doxorubicin-treated group in comparison with the control group.
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