Our aim is to develop a robust, high-spatial resolution and highly reproducible MRE methodology for the measurement of rapid functionally mediated changes in human brain viscoelasticity. Based on prior work in mice, we expect to observe changes in shear wavelength of ~2mm due to functional activation. Using a modified Ristretto fMRE pulse sequence to acquire control data in healthy volunteers, we evaluated the reproducibility of MRE measurements at 2.5-, 2- and 1.5-mm isotropic spatial resolution. Excellent intra-scan consistency was observed between two interleaved paradigm acquisitions at all resolutions with comparable data quality. Robust inter-scan repeatability was also observed.
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