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Abstract #1031

Development of robust MRE for measurement of high-speed functionally mediated changes in human brain viscoelasticity

Bin Deng1,2,3, W. Scott Hoge3,4, Shruti Mishra3,4, Giacomo Annio5, Ralph Sinkus5, and Samuel Patz3,4
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Radiology, Massachusetts General Hospital, Boston, MA, United States, 3Harvard Medical School, Boston, MA, United States, 4Radiology, Brigham and Women’s Hospital, Boston, MA, United States, 55. Laboratory for Vascular Translational Science (LVTS, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France

Our aim is to develop a robust, high-spatial resolution and highly reproducible MRE methodology for the measurement of rapid functionally mediated changes in human brain viscoelasticity. Based on prior work in mice, we expect to observe changes in shear wavelength of ~2mm due to functional activation. Using a modified Ristretto fMRE pulse sequence to acquire control data in healthy volunteers, we evaluated the reproducibility of MRE measurements at 2.5-, 2- and 1.5-mm isotropic spatial resolution. Excellent intra-scan consistency was observed between two interleaved paradigm acquisitions at all resolutions with comparable data quality. Robust inter-scan repeatability was also observed.

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