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Abstract #1062

Central vein sign occurrence on FLAIR* in neuropsychiatric systemic lupus erythematosus patients

Francesca Inglese1, Kenneth Hergaarden1, Pierre-Louis Bazin2, Gerda M. Steup-Beekman3, Tom J.W. Huizinga3, Jeroen de Bresser1, and Itamar Ronen1
1Department of radiology, Leiden University Medical Center, Leiden, Netherlands, 2Faculty of Social and Behavioural Sciences, University of Amsterdam, Amsterdam, Netherlands, 3Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

The central vein sign (CVS) is an imaging biomarker useful in multiple sclerosis (MS) diagnosis and to differentiate MS from other autoimmune diseases with inflammatory lesions, such as systemic lupus erythematosus with neuropsychiatric events (NP). The prevalence of CVS in SLE patients experiencing NP is unknown. We examined 16 NPSLE patients for presence of CVS using FLAIR* images, generated from FLAIR images acquired at 3T and T2*-weighted images acquired at 7T. Out of 491 white matter lesions, we found 4 confirmed and 1 suspected CVS lesions. Our data suggests that CVS may be present in random occurrence in NPSLE.

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