Abstract #1349

A General Framework for Automated and Accurate b-Matrix Calculation for dMRI Pulse Sequences

Lisha Yuan¹, Qing Li², Guojing Wei³, Hongjian He¹, and Jianhui Zhong⁴

¹Department of Biomedical Engineering, Center for Brain Imaging Science and Technology, Zhejiang University, Hangzhou, China, ²MR Collaborations, Siemens Healthcare Ltd., Shanghai, China, ³SHS DI MR R&D SZN LP, Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, ⁴Department of Imaging Sciences, University of Rochester, Rochester, NY, United States

Since both imaging and diffusion gradient pulses could lead to significant diffusion-related signal attenuation, one must account for the effect of all imaging and diffusion gradient pulses to achieve an accurate estimation of diffusion metrics and tensors. Based on a generalized definition of b matrix, a general framework for an automated and accurate b-matrix calculation was proposed in this study. Its correctness was verified in SE-diffusion sequence, and the importance of accurate inclusion of all gradient pulses was shown in both SE- and SPEN-diffusion sequence. The proposed method is suitable for accurate evaluation of diffusion effects in various sequences.

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