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Abstract #1349

A General Framework for Automated and Accurate b-Matrix Calculation for dMRI Pulse Sequences

Lisha Yuan1, Qing Li2, Guojing Wei3, Hongjian He1, and Jianhui Zhong4
1Department of Biomedical Engineering, Center for Brain Imaging Science and Technology, Zhejiang University, Hangzhou, China, 2MR Collaborations, Siemens Healthcare Ltd., Shanghai, China, 3SHS DI MR R&D SZN LP, Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, 4Department of Imaging Sciences, University of Rochester, Rochester, NY, United States

Since both imaging and diffusion gradient pulses could lead to significant diffusion-related signal attenuation, one must account for the effect of all imaging and diffusion gradient pulses to achieve an accurate estimation of diffusion metrics and tensors. Based on a generalized definition of b matrix, a general framework for an automated and accurate b-matrix calculation was proposed in this study. Its correctness was verified in SE-diffusion sequence, and the importance of accurate inclusion of all gradient pulses was shown in both SE- and SPEN-diffusion sequence. The proposed method is suitable for accurate evaluation of diffusion effects in various sequences.

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