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Abstract #1487

Improving Fidelity of Concentration Dependence in CEST- MRI using pH-insensitive Low Duty Cycle Saturation Pulse Trains

Julius Chung1 and Tao Jin1
1University of Pittsburgh, Pittsburgh, PA, United States

Low duty cycle π-pulsed CEST is an easy to implement method for exchange rate insensitive CE-MRI measurement that is dependent on labile proton concentration. In creatine phantoms with varying pH, decreasing duty cycle of π-pulse trains decreased pH dependence. In creatine phantoms of varying concentration and varied pH, exchange dependent relaxation asymmetry of π-pulsed CEST shows stronger linear dependence on concentration at lower duty cycles than continuous wave. Low duty cycle π-pulsed CEST may be useful in studies in which a change of chemical exchange rate (e.g., pH, catalyst concentration, and temperature changes) can interfere with accurate assessment of pathology.

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