Abstract #1791

Sodium NMR relaxation times of human skin as potential biomarkers for Type 2 Diabetes Mellitus

Daria V Fomina^1,2, Elnur G Sadykhov³, Petra Hanson^4,5, Christopher J Philp¹, Harpal S Randeva^4,5, J Paul O'Hare^4,5, Olga S Pavlova^3,6, Nikolay V Anisimov⁶, Alexander M Makurenkov³, Yury A Pirogov³, Thomas M Barber^4,5, Thomas Meersmann¹, and Galina E Pavlovskaya^1,2

¹SPMIC, School of Medicine, University of Nottingham, Nottingham, United Kingdom, ²NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom, ³Faculty of Physics, Lomonosov Moscow State University, Moscow, Russian Federation, ⁴Warwick Medical School, University of Warwick, Coventry, United Kingdom, ⁵Warwickshire Institute for the Study of Diabetes Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire, Coventry, United Kingdom, ⁶Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow, Russian Federation

Skin plays an important role in sodium regulation in the human body. As sodium interaction with macromolecules in biological tissue results in a bi-exponential T₂ relaxation, a sensitive characterization of the molecular environment of the sodium ions can be made. This allows us to investigate sodium relaxation times, T_2short and T_2long, in human skin samples from patients with and without Type 2 Diabetes Mellitus (T2DM) using high-resolution ²³Na MRS at high field 9.4T. We find that there is a significant elongation of T_2long in T2DM patients. This might be indicative of disease specific skin structure changes.

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