Abstract #1804

Triple-quantum-filtered Sodium MRI at 7T: Optimization of the Enhanced SISTINA Sequence Using FLORET k-space Trajectories

Qingping Chen^1,2,3, Wieland A. Worthoff¹, and N. Jon Shah^1,2,4,5

¹Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Germany, ²Department of Neurology, RWTH Aachen University, Aachen, Germany, ³Department of Biomedical Engineering, The University of Melbourne, Parkville, Australia, ⁴Institute of Neuroscience and Medicine 11, INM-11, JARA, Forschungszentrum Jülich, Germany, ⁵JARA - BRAIN - Translational Medicine, Aachen, Germany

It has been reported that enhanced SISTINA, one of the triple-quantum-filtered sodium MRI techniques, can selectively measure the distribution of restricted sodium, which may be sensitive to metabolic cellular dysfunction. In this work, the enhanced SISTINA sequence was optimized for 7T using FLORET, which has high k-space filling efficiency and good potential for undersampling. The optimized enhanced SISTINA sequence greatly improves the UTE image quality, while maintaining the multiple-quantum-filtered image performance and introducing incoherent randomness to the raw data. We believe the optimized enhanced SISTINA has promising potential for clinical applications with faster scans using compressed-sensing reconstruction in future.

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