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Abstract #1822

Glycogen Synthesis and Glucose Utilization at 3T using Localized Spectroscopy and Chemical Shift Imaging

Shun Kishimoto1, Jeffrey R Brender1, Jeeva Munasinghe2, Martin Lizak2, Yu Saito1, Kota Yamashita1, Otowa Yasunori1, Kazu Yamamoto1, James Mitchell1, and Murali C. Krishna1
1NIH/NCI, Bethesda,, MD, United States, 2NIH/NINDS, Bethesda,, MD, United States

Aberrant glycogen metabolism has been implicated in vitro as a possible causative factor in multiple disorders. Progress has been stymied due to the rapid degradation of glycogen post mortem and the lack of methods for measuring glycogen metabolism in vivo. We show here that glucose metabolism and local synthesis of glycogen can be measured in mice by short echo PRESS following a single bolus of unlabeled glucose using a standard 3T preclinical MRI using low rank reconstruction. Imaging of glycogen synthesis was possible at 9.4T by CSI, where it was found in mice to be centered on the olfactory bulb

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