Combining GE and SE signals enables quantification of several pertinent parameters making it useful in various applications. An 10-echo GESE sequence based on EPIK, known as EPI with keyhole, has been presented in our earlier work. This work employs an accelerated sequence implementation and aims to perform quantification of T2/T2* for both phantom and in vivo data. The method was configured to provide improved resolution within feasible TEs for brain scans, i.e. 1 minute. The quantified T2/T2* values were in good agreement with values from reference methods. Moreover, an SNR/tSNR analysis proves the signal and time gain from multi-shot acceleration.