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Abstract #1835

Software for T1ρ Mapping in the Knee: Addressing the Critical Role of Motion Correction

Artem Mikheev1, Louisa Bokacheva1, Azadeh Sharafi1, Ravinder Regatte1, and Henry Rusinek1
1Department of Radiology, New York University School of Medicine, New York, NY, United States

T1ρ mapping enables detecting early changes in the knee cartilage associated with osteoarthritis. Reproducible T1ρ measurements are challenging because of the motion artifacts arising from a long acquisition time of images at multiple spin-lock times. We implemented a new elastic motion correction method and applied it to T1ρ-weighted acquisitions in 20 subjects with normal knees and early osteoarthritis. The T1ρ voxel maps in articular cartilage generated from motion-corrected images showed significantly lower variability compared to maps derived from uncorrected images. The finding underscores the importance of motion correction in T1ρ mapping of the knee.

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