Abstract #1868

Pancreatic fatty infiltration and iron in thalassemia major

Antonella Meloni¹, Mario Nobile², Laura Pistoia¹, Vincenzo Positano¹, Emanuele Grassedonio², Petra Keilberg¹, Francesco Sorrentino³, Maurizio Caniglia⁴, Annamaria Carrà⁵, Domenico Visceglie⁶, Massimo Midiri², and Alessia Pepe¹

¹MRI Unit, Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy, ²Policlinico "Paolo Giaccone", Palermo, Italy, ³Ospedale "Sant'Eugenio", Roma, Italy, ⁴Azienda Ospedaliera "S. Maria Misericordia" di Perugia, Perugia, Italy, ⁵Ospedale “G. Da Saliceto”, Piacenza, Italy, ⁶Ospedale “Di Venere”, Bari, Italy

Pancreatic fatty replacement is present in more than three-quarters of patients with thalassemia major and it is associated with ageing. Pancreatic fatty replacement is associated to pancreatic iron overload, with a pancreatic T2* value <18 predicting its presence with a sensitivity of 75.6% and a specificity of 85.4%.

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