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Abstract #1868

Pancreatic fatty infiltration and iron in thalassemia major

Antonella Meloni1, Mario Nobile2, Laura Pistoia1, Vincenzo Positano1, Emanuele Grassedonio2, Petra Keilberg1, Francesco Sorrentino3, Maurizio Caniglia4, Annamaria Carrà5, Domenico Visceglie6, Massimo Midiri2, and Alessia Pepe1
1MRI Unit, Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy, 2Policlinico "Paolo Giaccone", Palermo, Italy, 3Ospedale "Sant'Eugenio", Roma, Italy, 4Azienda Ospedaliera "S. Maria Misericordia" di Perugia, Perugia, Italy, 5Ospedale “G. Da Saliceto”, Piacenza, Italy, 6Ospedale “Di Venere”, Bari, Italy

Pancreatic fatty replacement is present in more than three-quarters of patients with thalassemia major and it is associated with ageing. Pancreatic fatty replacement is associated to pancreatic iron overload, with a pancreatic T2* value <18 predicting its presence with a sensitivity of 75.6% and a specificity of 85.4%.

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