Abstract #1869

Relationship Between Pancreatic Proton Density Fat Fraction and HOMA-IR in Individuals With and Without HIV Infection

Edgar Adrian Castellanos¹, Susan Noworolski², Diana Alba³, Peter Hunt³, and Suneil Koliwad³

¹Department of Radiology and Biomedical Imaging, University of California , San Francisco, San Francisco, CA, United States, ²Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ³Department of Medicine and Diabetes Center, University of California, San Francisco, San Francisco, CA, United States

Individuals with HIV+ infection have a higher rate of progression to type 2 diabetes mellitus (T2DM), although the mechanisms are not fully understood. Pancreatic proton density fat fraction (PDFF) measures were shown to not differ between individuals with HIV+ (n=16) and controls (n=16). However, when stratified to high versus low measures of insulin resistance (using HOMA-IR), individuals with HIV+ infection (but not controls), who had high HOMA-IR had higher pancreatic PDFF than those with low HOMA-IR, p=0.01. These results suggest pancreatic PDFF may be useful to monitor in HIV+ infection.

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