The cerebral cortex is comprised of short column structures that span across the cortical layers between white matter and the pial surface. Subtle abnormalities in this microstructure, which may not be visible on anatomical scans, can have a large effect on brain function and development. In an effort to delineate such abnormalities, this study presents a technique to accurately and effectively observe the cortical depth dependence of diffusion anisotropy and diffusivity in-vivo using sub-millimeter isotropic resolution diffusion tensor imaging.
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