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Abstract #2028

Surface based analysis of cortical diffusion metrics: associations with cortical myeloarchitecture and underlying white matter anisotropy

Tonima Sumya Ali1 and Fernando Calamante1,2
1School of Biomedical Engineering, The University of Sydney, Sydney, Australia, 2Sydney Imaging, The University of Sydney, Sydney, Australia

We employ structural and diffusion MRI metrics to evaluate their effectiveness for cortical segregation based on myelination, neurite density and microstructure in cortex. Three cortical measures (T1w/T2w, FA and total apparent fibre density, AFDtotal, demonstrated significant inter-correlations. Two track-weighted parameters (FOD and FA, measured in white matter adjacent to cortex), also showed significant correlations to cortical FA and AFDtotal. The spatial cortical patterns corresponding to these parameters suggest they provide complementary information on cortical features, and may help improve our understanding of cortical organisation in vivo and eventually lead to a further multi-parametric model for cortical parcellation.

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