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Abstract #2029

Generalized anisotropy profiles distinguish cortical and subcortical structures in ex vivo diffusion MRI

Robert Jones1, Qiyuan Tian1, Chiara Maffei1, Jean Augustinack1, Aapo Nummenmaa1, Susie Huang1, and Anastasia Yendiki1
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States

We propose an approach to extracting a generalized anisotropy profile from the ensemble average propagator, which can be obtained either from diffusion spectrum imaging (DSI) data or from a generalized DSI analysis of diffusion MRI data acquired on q-shells. We validate this approach on data from ex vivo human tissue, acquired at 9.4T with 0.25 mm spatial resolution. We show that the proposed anisotropy profile can be used to distinguish between various white- and gray-matter structures, revealing fundamental differences in their microstructure.

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