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Abstract #2030

Comparison of high-resolution DTI in ex vivo newborn and adult marmoset brain 

Emmanuelle Weber1, Erpeng Dai1, Christoph Leuze1, Nikola T. Markov2, Nicholas Tran1, Mariko Bennett1, Samuel Baker1, Kerriann Casey1, Kalanit Grill-Spector1, Keren Haroush1, and Jennifer A. McNab1
1Stanford, Stanford, CA, United States, 2Buck Institute, Novato, CA, United States

High-resolution (0.15 mm isotropic) diffusion MRI of newborn and an adult marmoset brains were acquired. For the adult marmoset brain the diffusion MRI data of anterior and posterior parts of the brain were separately acquired and subsequently co-registered. Across the whole brain, fractional anisotropy (FA) was lower and mean diffusivity (MD) was higher (Fig. 4) in the newborn compared to the adult. The biggest differences were observed in white matter. Cingulate cortex region A25 showed the smallest difference, which aligns with previous studies showing its early stage development

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