Abstract #2031

Is calibration necessary to relate NODDI, NODDIDTI, WMTI to axonal volume fraction? - A joint ex vivo MRI and histology study.

Sebastian Papazoglou¹, Mohammad Ashtarayeh¹, Martina F. Callaghan², Mark D. Does^3,4,5,6, and Siawoosh Mohammadi^1,7

¹Department of Systems Neurosciences, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ²Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, ³Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ⁴Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, ⁵Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ⁶Department of Electrical Engineering, Vanderbilt University, Nashville, TN, United States, ⁷Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

It is unknown whether the accuracy of DWI-model based estimates of the axonal water fraction could be enhanced by additional calibrations. In this study we compared three DWI-models (WMTI, NODDI, NODDIDTI) using histology data as gold standard in ex vivo mouse models with a broad dynamic range of axonal metrics. We found that all DWI-models improved with additional calibration. Models with fixed diffusivities benefited efficiently from an additional scaling, while the WMTI model was stronger affected by an additional offset. Furthermore, without any additional calibration, the axonal compartment biomarker from NODDIDTI could explain the data better than WMTI or NODDI.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.