Meeting Banner
Abstract #2032

b-Value Dependency of Diffusion Parameters Derived from the DTI and DKI Models in Postmortem Human Brain Hemispheres

Junye Yao1, Zihan Zhou1, Benjamin C. Tendler2, Karla L. Miller2, Lei Zhang3, Keqing Zhu3, Aimin Bao3, Hongjian He1, and Jianhui Zhong1,4
1Center for Brain Imaging Science and Technology, College of Biomedical Engineering and Instrumental, Zhejiang University, Hangzhou, China, 2Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, London, United Kingdom, 3National Human Brain Bank for Health and Disease, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, China, 4Department of Imaging Sciences, University of Rochester, Rochester, NY, United States

Diffusion weighted images of formalin-fixed human brain hemispheres were used to study b-value dependence of diffusion parameters with the diffusion tensor and diffusion kurtosis model. Consistent decreases of FA with increasing b-values were observed in all hemispheres. Meanwhile, the mean kurtosis was found to increase with the discrepancy of FA between high and low b-value datasets. These results indicate that the b-value dependence of FA could be explained by non-gaussian diffusion effects consistent with tissue microstructure.

This abstract and the presentation materials are available to members only; a login is required.

Join Here