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Abstract #2120

Influence of portal vein occlusion on portal flow and liver elasticity in an animal model

Simon Chatelin1, Raoul Pop2,3, Céline Giraudeau2, Khalid Ambarki4, Ning Jin5, François Séverac1,6, Elodie Breton1, and Jonathan Vappou1
1ICube, UMR 7357 CNRS, University of Strasbourg, Strasbourg, France, 2IHU-Strasbourg, Institute of image-guided surgery, Strasbourg, France, 3Interventional Neuroradiology Department, University Hospitals of Strasbourg, Strasbourg, France, 4Siemens Healthcare SAS, Saint Denis, France, 5Siemens Medical Solutions USA, Inc., Chicago, IL, United States, 6Public Healthcare Department, University Hospitals Strasbourg, Strasbourg, France

Hepatic fibrosis causes an increase in the liver stiffness, a parameter measured by elastography and widely used as diagnosis method. This study aims at determining the extent to which a portal occlusion due to concomitant portal vein thrombosis can also affect these mechanical properties. Portal vein occlusion was generated by progressive inflations of a balloon catheter in the portal vein of four swines. The portal flow and liver stiffness were investigated using 4D-flow MRI and MR-Elastography. This vascular mechanism is shown to be sufficient to attenuate the increase in stiffness due to moderate fibrosis and may lead to false-negative diagnosis.

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