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Abstract #2140

Study of Gd-EOB-DTPA T1mapping in quantitatively staging hepatic fibrosis in a rabbit model

Zuhui Zhu1, Wei Xing1, Haifeng Liu1, Qing Wang1, Yanan Du1, Yufeng Li1, and Jilei Zhang2
1Department of Radiology, third Affiliated Hospital of Soochow University & Changzhou First People's Hospital, Changzhou, China, 2Philips Healthcare, Shanghai, China

To explore parameters obtained by Gd-EOB-DTPA T1 mapping and extracellular volume fraction in evaluating hepatic fibrosis (HF) in a rabbit model. The HF model was established by carbon tetrachloride (CCl4).Rabbits underwent pathological examination to determine the HF stage using the metavir classification system. Parameters including T1native, T110 min, T120 min, ECV10 min and ECV20 min were measured and compared among the different HF stages using spearman correlation coefficients and receiver operating characteristic curve. The AUC of T120 min was higher than that of other quantitative parameters. T1 mapping parameters and ECV fraction are closely associated with HF progression.

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