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Abstract #2530

Multiparametric MR imaging in diabetic nephropathy: New insights to evaluate early diabetic nephropathy noninvasively

Akira Yamamoto1, Tsutomu Tamada2, Yu Ueda3, Takeshi Fukunaga2, and Atsushi Higaki2
1Radiology, Kawasaki Medical School, Kurashiki, Japan, 2Kawasaki Medical School, Kurashiki, Japan, 3Phillips Japan, Tokyo, Japan

The purpose of this study was to identify the changes in multiparametric magnetic resonance imaging (MRI) findings in early diabetic nephropathy. Measurements were made of the renal cortex and renal medulla T2 values, T2* values and R2* values, as well as optimal TI, inverted TI value and cortico-medullary difference on optimal TI in SSFP with ssIR pulse with multi TI. Also, renal cortical thickness and renal length were measured, representing morphological changes. Significant differences were seen between the healthy and early diabetic nephropathy (grade1 and grade2) in T2 values of cortex and T2* values of medulla. This study suggests the possibility that MRI using the values of T2 of cortex and T2* of medulla can be used to evaluate early diabetic nephropathy non-invasively and in a short period of time.

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