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Abstract #2545

Mono-exponential, bi-exponential, and kurtosis diffusion-weighted imaging for renal cold ischemia-reperfusion injury in rats

Lihua Chen1, Yan Ren1, Yizhong Yuan2, Jipan Xu2, Jinxia Zhu3, Xuening Zhang4, Robert Grimm5, and Wen Shen1
1Tianjin First Center Hospital, Tianjin, China, 2First Central Hospital Institute, Tianjin Medical University, Tianjin, China, 3Siemens Healthcare Ltd., Beijing, China, 4Second Hospital of Tianjin Medical University, Tianjin, China, 5Siemens Healthcare GmbH, Erlangen, Germany

Renal dysfunction evaluations after renal cold ischemia-reperfusion injury (CIRI) has important clinical significance for prolonging donor kidney preservation times and improving the survival rates of transplanted kidneys. Diffusion-weighted imaging (DWI) has been accepted for microstructure change evaluations of renal function. In this study, a CIRI rat model was established and compared with a sham-operation group. The value of mono-exponential, bi-exponential, and kurtosis DWI models was compared to evaluate renal changes at different time points after CIRI surgery. The results showed that the bi-exponential and kurtosis models were more sensitive for detecting renal changes compared with the mono-exponential model.

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