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Abstract #2883

Functional Segmentation and Reconstruction for High-Definition DCE MRI Exploiting Vascular Heterogeneity priors

Joon Sik Park1, Seung-Hong Choi2, Chul-Ho Sohn2, and Jaeseok Park1,3
1Biomedical Engineering, Sungkyunkwan University, Gyunggido, Korea, Republic of, 2Seoul National University Hospital, Seoul, Korea, Republic of, 3Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Gyunggido, Korea, Republic of

In this work, we propose a novel, joint functional segmentation and reconstruction directly from largely incomplete DCE measurements exploiting multi-scale vascular heterogeneity priors to achieve high-definition whole brain DCE MRI. Experimental studies were performed in patients with brain tumor to investigate the feasibility of the proposed method in jointly visualizing vascular structures and functions from a single measurement after administering contrast agents. We demonstrated that the proposed method outperforms conventional methods in delineating angiographic structures, functional segment maps, and corresponding perfusion-permeability maps

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