In this work, we propose a novel, joint functional segmentation and reconstruction directly from largely incomplete DCE measurements exploiting multi-scale vascular heterogeneity priors to achieve high-definition whole brain DCE MRI. Experimental studies were performed in patients with brain tumor to investigate the feasibility of the proposed method in jointly visualizing vascular structures and functions from a single measurement after administering contrast agents. We demonstrated that the proposed method outperforms conventional methods in delineating angiographic structures, functional segment maps, and corresponding perfusion-permeability maps
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