In the current study, we aim to investigate the spatiotemporal profile of negative BOLD response evoked by somatosensory stimulation in mouse. Positive BOLD response was observed in contralateral primary somatosensory cortex (S1) by forepaw somatosensory stimulation, while negative BOLD response was observed in the bilateral barrel field of somatosensory cortex (Scbf). The amplitude of BOLD response in Scbf was negatively correlated with positive BOLD response in S1, while negative BOLD response lasted longer than positive BOLD response. These results indicate that origin of negative BOLD response could be neuronal activity, but neurovascular coupling is not similar as positive BOLD response.
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