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Abstract #2931

Correlation of negative and positive BOLD signal change in the cerebral cortex by somatosensory stimulation in mice

Tomokazu Tsurugizawa1, Boucif Djemai2, and Kazumi Kasahara1
1Human Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan, 2NeuroSpin/CEA-Saclay, Gif-sur-Yvette, France

In the current study, we aim to investigate the spatiotemporal profile of negative BOLD response evoked by somatosensory stimulation in mouse. Positive BOLD response was observed in contralateral primary somatosensory cortex (S1) by forepaw somatosensory stimulation, while negative BOLD response was observed in the bilateral barrel field of somatosensory cortex (Scbf). The amplitude of BOLD response in Scbf was negatively correlated with positive BOLD response in S1, while negative BOLD response lasted longer than positive BOLD response. These results indicate that origin of negative BOLD response could be neuronal activity, but neurovascular coupling is not similar as positive BOLD response.

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