We aimed to investigate the patterns of cerebral perfusion changes in early drug-naive PD patients with mild cognitive impairment (PD-MCI). Voxel-wise cerebral blood flow (CBF) were compared among PD-MCI patients, PD patients with normal cognition (PD-NC) and healthy controls. Increased CBF was detected in the right anterior cingulate cortex in the PD-MCI group as compared to the controls, as well as higher perfusion in the right middle frontal gyrus and superior frontal gyrus relative to PD-NC. Cerebral hyper-perfusion in frontal lobe might be associated with cognitive decline in early de novo PD.
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