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Abstract #3034

Simultaneous multi-parameter mapping to characterize Parkinson’s Disease using strategically acquired gradient echo imaging 

Yu Shen1, Xianchang Zhang2, Yan Bai1, Yaping Wu1, Ewart Mark Haacke3, Bo Wu4, Yongsheng Chen4, Rui Zhang1, Rushi Chen1, Wei Wei1, and Meiyun Wang1
1Department of Medical Imaging, Henan Provincial People’s Hospital & Zhengzhou University, Zhengzhou, China, 2MR Collaboration, Siemens Healthcare Ltd. Beijing China, Beijing, China, 3Wayne State University, Detroit, MI, United States, 4Shanghai Zhuyan Medical Technology Company, Shanghai, China

Scanning patients with Parkinson’s disease (PD) is challenging because of tremors. Strategically acquired gradient echo (STAGE) imaging can acquire seven quantitative images relatively quickly. This method could provide comprehensive evaluations of cerebral alterations in PD patients while reducing motion artifacts. This study compared T1, T2*, R2*, and susceptibility-weighted imaging mapping (SWIM) acquired with STAGE imaging between 15 PD patients and 15 healthy controls (HC). Significant differences were found for the T1 and T2* values in several brain areas between PD and HC, suggesting that STAGE imaging is a convenient and powerful tool to investigate PD.

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