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Abstract #3061

Mapping correlation spectra of T1 and mean diffusivity in the human brain

Alexandru V Avram1,2, Joelle E Sarlls3, and Peter J Basser1
1Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States, 2Center for Neuroscience and Regenerative Medicine, The Henry Jackson Foundation, Bethesda,, MD, United States, 3National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States

We develop a novel clinical pulse sequence with integrated inversion recovery (IR) and isotropic diffusion encoding (IDE) preparations for mapping correlation spectra of subvoxel T1 and mean diffusivities (MD) from measurements acquired with a wide range of joint T1-MD weightings. We evaluated the performance of the pulse sequence and spectral reconstruction pipeline using data from numerical simulations, a calibrated MRI phantom and healthy volunteers. Preliminary results suggest that maps of subvoxel T1-MD spectra show tissue-specific components in the human brain. Quantifying the heterogeneity of T1-diffusion properties in microscopic water pools could improve biological specificity in many clinical applications.

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