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Abstract #3062

BUDA-SAGE with unsupervised denoising enables fast, distortion-free, high-resolution T2, T2*, iron and myelin susceptibility mapping

Zijing Zhang1,2, Long Wang3, Hyeong-Geol Shin4, Jaejin Cho2, Tae Hyung Kim2, Jongho Lee4, Jinmin Xu1, Tao Zhang3, Huafeng Liu1, and Berkin Bilgic2
1State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, China, 2Department of Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts general hospital, Boston, MA, United States, 3Subtle Medical Inc, Menlo Park, CA, United States, 4Laboratory for Imaging Science and Technology (LIST), Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of

We propose BUDA-SAGE, an efficient echo‐planar imaging (EPI) sequence for quantitative mapping. The acquisition includes multiple T2*-, T2- and T2-weighted contrasts. We alternate the phase-encoding polarities across the shots in this multi-shot navigator-free acquisition to eliminate geometric distortion. An unsupervised Self2Self (S2S) neural network (NN) was utilized to perform denoising after BUDA reconstruction to achieve 1×1×2 mm3 resolution with high SNR. We demonstrate the ability of BUDA-SAGE to provide whole-brain, distortion-free, high-resolution multi-contrast images and quantitative T2, T2* maps in 50 seconds, and separate para- and dia-magnetic susceptibility maps in 140 seconds.

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