Abstract #3216

Correlation of global and regional hyperpolarised 129-Xenon MRI with quantitative CT in patients with idiopathic pulmonary fibrosis

James A Eaden^1,2, Guilhem J Collier¹, Ho-Fung Chan¹, Nicholas D Weatherley^1,2, Graham Norquay¹, Smitha Rajaram³, Andy Swift^1,3, Ronald A Karwoski⁴, Brian Bartholmai⁴, Stephen M Bianchi², and Jim M Wild^1,5

¹POLARIS, MRI unit, Department of Infection Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom, ²Academic Directorate of Respiratory Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom, ³Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom, ⁴Mayo Clinic, Rochester, MN, United States, ⁵Insigneo institute, University of Sheffield, Sheffield, United Kingdom

Correlations between ¹²⁹Xe MRI measures of microstructure and gas exchange and CALIPER CT variables were evaluated both globally and regionally in IPF patients. To date, 27 subjects have undergone both baseline ¹²⁹Xe DW-MRI and CT with 13 of them having baseline dissolved ¹²⁹Xe imaging using a 3D radial spectroscopic method. Our findings demonstrate several significant correlations between dissolved ¹²⁹Xe MRI (RBC:TP, TP:Gas, RBC:Gas) and CALIPER variables. Vessel related structures % was the only CALIPER variable that showed a significant correlation between ¹²⁹Xe RBC:TP globally and in all lung zones. There were no significant correlations between ¹²⁹Xe DW-MRI and CALIPER variables.

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