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Abstract #3216

Correlation of global and regional hyperpolarised 129-Xenon MRI with quantitative CT in patients with idiopathic pulmonary fibrosis

James A Eaden1,2, Guilhem J Collier1, Ho-Fung Chan1, Nicholas D Weatherley1,2, Graham Norquay1, Smitha Rajaram3, Andy Swift1,3, Ronald A Karwoski4, Brian Bartholmai4, Stephen M Bianchi2, and Jim M Wild1,5
1POLARIS, MRI unit, Department of Infection Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom, 2Academic Directorate of Respiratory Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom, 3Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom, 4Mayo Clinic, Rochester, MN, United States, 5Insigneo institute, University of Sheffield, Sheffield, United Kingdom

Correlations between 129Xe MRI measures of microstructure and gas exchange and CALIPER CT variables were evaluated both globally and regionally in IPF patients. To date, 27 subjects have undergone both baseline 129Xe DW-MRI and CT with 13 of them having baseline dissolved 129Xe imaging using a 3D radial spectroscopic method. Our findings demonstrate several significant correlations between dissolved 129Xe MRI (RBC:TP, TP:Gas, RBC:Gas) and CALIPER variables. Vessel related structures % was the only CALIPER variable that showed a significant correlation between 129Xe RBC:TP globally and in all lung zones. There were no significant correlations between 129Xe DW-MRI and CALIPER variables.

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