Global 129Xe MRS was acquired in the lungs synchronously with an ECG recording to enable association of dissolved-phase 129Xe signal dynamics with the cardiac cycle. Time-domain Voigt fitting was used to calculate resonance parameters corresponding to 129Xe in red blood cells and tissue/blood plasma in the lungs. Positive and negative signal changes of 129Xe in the blood were found to be associated with ventricular systole and diastole in a healthy volunteer.
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