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Abstract #3565

Feasibility of Xenon Polarization Transfer Contrast Imaging using Continuous RF Irradiation

Faraz Amzajerdian1, Tahmina Achekzai1, Luis Loza1, Hooman Hamedani1, Yi Xin1, Harilla Profka1, Ian Duncan1, Stephen Kadlecek1, Kai Ruppert1, and Rahim Rizi1
1University of Pennsylvania, Philadelphia, PA, United States

Xenon-polarization Transfer Contrast (XTC) imaging is a powerful technique for quantifying exchange rates between gas- and dissolved-phase xenon compartments and involves a series of radiofrequency (RF) saturation pulses applied to the targeted dissolved-phase resonance. Although increasing the number of pulses and their spacing generates greater contrast, it also increases acquisition time. In this work, in an effort to reduce acquisition time, particularly for free-breathing imaging protocols, we explored the use of continuous RF irradiation to depolarize dissolved-phase xenon, with the goal of producing results similar to those achieved with pulsed saturations, but in a significantly shorter time period.

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