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Abstract #3566

Reproducibility Study Measuring Ventilation, Gas Exchange and Surface-to-Volume Using Hyperpolarized Xenon in Free-breathing Human Subjects

Hooman Hamedani1, Stephen Kadlecek1, Faraz Amzajerdian1, Ryan Baron1, Kai Ruppert1, Ian Duncan1, Yi Xin1, Luis Loza1, Tahmina Achekzai1, Maurizio Cereda1, Kevin Ma1, David DiBardino1, and Rahim Rizi1
1University of Pennsylvania, Philadelphia, PA, United States

We have previously shown the advantages of multi- over single-breath imaging of lung ventilation using HP gas MRI, and have recently introduced our approach for comprehensively assessing the lung function during a tidal breathing scheme to quantify ventilation and dissolved parameters of xenon distribution. Here, we presented the repeatability of the imaging markers in a healthy subject and a patient with severe chronic obstructive pulmonary disease (COPD) with persisting cough. We have shown that the technical back-to-back reproducibility of measuring lung function with our scheme is excellent in a healthy subject and satisfactory in a COPD subject with persisting cough.

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